Tolerance criteria for continuous inhalation exposure to toxic material.
[Part] II,
Effects on animals of a 90-day exposure to H₂S, methyl mercaptan, indole, and a mixture of H₂S, methyl mercaptan, indole, and skatole /
Dr. Curtis Sandage.

Description

Main Author

Sandage, Curtis

Language(s)

English

Published

Wright-Patterson Air Force Base, Ohio : Biomedial Laboratory, Aerospace Medical Laboratory, Aeronautical Systems Division, Air Force Systems Command, U.S. Air Force, 1961.

Subjects

Indole > Indole / Physiological effect.
Organosulfur compounds > Organosulfur compounds / Physiological effect.
Hydrogen sulfide > Hydrogen sulfide / Physiological effect.
Life support systems (Space environment)
Space cabin atmospheres.
Space medicine > Space medicine / Research.

Summary

Physiological changes in rats, mice, and monkeys were studied during continuous 90-day exposure to controlled atmospheres of toxic vapors and gases which might be expected to accumulate within a space capsule. Concentrations of test chemicals were those recognized as Industrial Threshold Limit Values and included: (a) hydrogen sulfide (20 ppm), (b) methyl mercaptan (50 ppm), (c) indole (10.5 ppm), and (d) a mixture of these three compounds plus skatole (3.5 ppm). Mortality rates were high only in the group exposed to a mixture of four compounds. There was evidence that animals can adapt to tolerate otherwise lethal concentrations of compounds, and there there are great individual differences in the ability to so adapt.

Physical Description

iv, 36 pages ; illustrations, tables ; 28 cm.

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