Vectorcardiographic changes during intracoronary injections /
Raphael F. Smith, J. Warren Harthorne, and Charles A. Sanders..

Description

Main Author

Smith, Raphael F.

Related Names

Sanders, Charles A., author.
Harthorne, J. Warren, author.
United States. Navy Department.
United States. Manned Spacedraft Center.
United States. National Aeronautics and Space Administration.
Naval Aerospace Medical Institute (U.S.)

Language(s)

English

Published

Pensacola, Florida : U.S. Naval Aerospace Medical Institute, U.S. Naval Aviation Medical Center, 1967.

Subjects

Electrophysiology.
Vertigo.
Cardiovascular system > Cardiovascular system / Diseases.
Vectorcardiography.

Summary

To determine mechanisms of myocardial toxicity of radiopaque media and to correlate specifically induced changes in the composition of coronary artery blood with the changes in the surface electrocardiogram, simultaneous recordings were made from Frank leads X, Y, and Z during intracoronary injections of radiopaque media and special test solutions in 19 patients. With injections of sodium-containing radiopaque media into the right coronary system the mean T vector increased in magnitude and deviated to the left and superiorly. With left coronary injections the T vector increased in magnitude and shifted to the right, downward, and anteriorly. Changes in the QRS complex were less constant but when present, consisted of slight prolongation of the QRS duration and shift of the QRS vector toward the area of myocardium perfused by the coronary system injected. Similar T vector changes could be produced by intracoronary injections of saline solutions, but minimal or no changes were observed with injections of hypertonic mannitol, Ringer's solution, hypoxic blood, plasma, and 5 per cent dextrose in water. It is concluded that the T wave changes are caused by regional prolongation of the repolarization process, presumably due to extracellular sodium excess or sodium-calcium antagonism. Delay of the repolarization process and the resulting potential difference may be responsible for reentrant excitation and the ventricular arrhythmias observed during coronary angiography. (Author).

Note

"This research was supported in part by a contract with the Manned Spacedraft Center, National Aeronautics and Space Administration."--title page.
"Bureau of Medicine and Surgery, MR005.20-0048-3, NASA Order T-23237."--title page.
Joint report of the United States Naval Aerospace Medical Institute and the National Aeronautics and Space Administration.--cover.
"13 February 1967."

Physical Description

28 pages : illustrations ; 28 cm.

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