Architecture-Function Analysis of the Kinetochore Reveals the Mechanism of Spindle Assembly Checkpoint Signaling
|Main Author:||Aravamudhan, Pavithra.|
Mechanism of mitotic checkpoint that ensures accurate chromosome segregation during cell division.
Developmental of biophysical tools to probe and characterize macromolecular structures.
Macromolecular protein architecture of kinetochore shapes emergent functions.
Biochemical parameters provide handles to modulate checkpoint signaling.
High resolution and fluorescence microscopy approaches to address biological problems.
Quantitative approaches to define checkpoint signaling to predict implications in diseased conditions like cancer.
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|Item Link||Original Source|
|Limited (search only)||University of Michigan|